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Effects of A1 adenosine receptor agonism using N6-cyclohexyl-2'-O-methyladenosine in patients with left ventricular dysfunction.

Authors
  • Bertolet, B D
  • Anand, I S
  • Bryg, R J
  • Mohanty, P K
  • Chatterjee, K
  • Cohn, J N
  • Khurmi, N S
  • Pepine, C J
Type
Published Article
Journal
Circulation
Publication Date
Sep 15, 1996
Volume
94
Issue
6
Pages
1212–1215
Identifiers
PMID: 8822971
Source
Medline
License
Unknown

Abstract

A1 adenosine receptor agonism with SDZ-WAG 994 resulted in no significant hemodynamic changes at rest in this subset of patients with left ventricular dysfunction. An increase in the PR interval and atrial natriuretic peptide level, consistent with adenosine A1 receptor-mediated activity, was observed. In addition, an increase in the norepinephrine level was observed, suggesting a role for adenosine as a peripheral nervous system neuromodulator.

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