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Effects of 4- and 6-h Time-Restricted Feeding on Weight and Cardiometabolic Health: A Randomized Controlled Trial in Adults with Obesity.

Authors
  • Cienfuegos, Sofia1
  • Gabel, Kelsey1
  • Kalam, Faiza1
  • Ezpeleta, Mark1
  • Wiseman, Eric1
  • Pavlou, Vasiliki1
  • Lin, Shuhao1
  • Oliveira, Manoela Lima1
  • Varady, Krista A2
  • 1 Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, USA.
  • 2 Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, USA. Electronic address: [email protected]
Type
Published Article
Journal
Cell metabolism
Publication Date
Sep 01, 2020
Volume
32
Issue
3
Identifiers
DOI: 10.1016/j.cmet.2020.06.018
PMID: 32673591
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Time-restricted feeding (TRF) regimens have grown in popularity; however, very few studies have examined their weight-loss efficacy. We conducted the first human trial (Clinicaltrials.gov NCT03867773) to compare the effects of two popular forms of TRF (4 and 6 h) on body weight and cardiometabolic risk factors. Adults with obesity were randomized to 4-h TRF (eating only between 3 and 7 p.m.), 6-h TRF (eating only between 1 and 7 p.m.), or a control group (no meal timing restrictions). After 8 weeks, 4- and 6-h TRF produced comparable reductions in body weight (∼3%), insulin resistance, and oxidative stress, versus controls. Energy intake was reduced by ∼550 kcal/day in both TRF groups, without calorie counting. These findings suggest that 4- and 6-h TRF induce mild reductions in body weight over 8 weeks and show promise as interventions for weight loss. These diets may also improve some aspects of cardiometabolic health. Copyright © 2020 Elsevier Inc. All rights reserved.

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