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Effects of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) on cardiac function in perfused guinea-pig heart.

Authors
  • Saeki, S
  • Masugi, F
  • Ogihara, T
  • Otsuka, A
  • Kumahara, Y
  • Watanabe, K
  • Tamura, K
  • Akashi, A
  • Kumagai, A
Type
Published Article
Journal
Life Sciences
Publisher
Elsevier
Publication Date
Jul 29, 1985
Volume
37
Issue
4
Pages
325–329
Identifiers
PMID: 4010479
Source
Medline
License
Unknown

Abstract

The direct cardiac action of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) was studied in isolated perfused guinea-pig heart preparations. PAF produced a fall in left ventricular pressure, decreases in the rate of rise of the left ventricular pressure (dp/dt) and coronary flow, but had no effect on heart rate. These results indicate that PAF is a cardiodepressant with inotropic selectivity and this effect on heart is blocked by CV-3988, a specific PAF antagonist.

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