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Effects of a 1,3-diacylglycerol oil-enriched diet on postprandial lipemia in people with insulin resistance.

Authors
  • Reyes, Gissette
  • Yasunaga, Koichi
  • Rothenstein, Eileen
  • Karmally, Wahida
  • Ramakrishnan, Rajasekhar
  • Holleran, Stephen
  • Ginsberg, Henry N
Type
Published Article
Journal
Journal of lipid research
Publication Date
Mar 01, 2008
Volume
49
Issue
3
Pages
670–678
Identifiers
PMID: 18089891
Source
Medline
License
Unknown

Abstract

Postprandial hypertriglyceridemia is common in individuals with insulin resistance, and diets enriched in 1,3-diacylglycerol (DAG) may reduce postprandial plasma triglycerides (PPTGs). We enrolled 25 insulin-resistant, nondiabetic individuals in a double-blind, randomized crossover trial to test the acute and chronic effects of a DAG-enriched diet on PPTG. Participants received either DAG or triacylglycerol (TAG) oil, in food products, for 5 weeks. Fasting lipids, and two separate postprandial tests, one with DAG oil and one with TAG oil, were performed at the end of each 5 week diet period. We found no acute or chronic effects of DAG oil on PPTG. Thus, neither the DAG oil PPTG (h/mg/dl) on a chronic TAG diet [area under the curve (AUC) = 503 +/- 439] nor the TAG oil PPTG on a chronic DAG diet (AUC = 517 +/- 638) was different from the TAG oil PPTG on a chronic TAG diet (AUC = 565 +/- 362). Five weeks of a DAG-enriched diet had no acute or chronic effects on PPTG in insulin-resistant individuals. We suggest further studies to evaluate the effects of DAG on individuals with low and high TG levels.

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