The effectiveness of spinosad and temephos for the control of mosquito larvae was evaluated in a tire dump in Allende, Nuevo Leon, Mexico. Three groups of 12 to 17 tires located in tree shade were utilized for this study. After the larvicides were applied, samples were collected weekly from 7 randomly chosen tires. The data showed a significant difference between the larvicides and control. Under the conditions of the present study, the effectiveness of spinosad against mosquito larvae was similar to that of temephos, both being effective for up to 91 days postapplication. In addition, spinosad allowed the establishment of the mosquito predator Toxorhynchites sp.