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Effectiveness of Screening and Treatment Approaches for Schistosomiasis and Strongyloidiasis in Newly-Arrived Migrants from Endemic Countries in the EU/EEA: A Systematic Review

Authors
  • agbata, eric n.
  • morton, rachael l.
  • bisoffi, zeno
  • bottieau, emmanuel
  • greenaway, christina
  • biggs, beverley-a.
  • montero, nadia
  • tran, anh
  • rowbotham, nick
  • arevalo-rodriguez, ingrid
  • myran, daniel t.
  • noori, teymur
  • alonso-coello, pablo
  • pottie, kevin
  • requena-méndez, ana
Publication Date
Dec 20, 2018
Source
MDPI
Keywords
Language
English
License
Green
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Abstract

Ottawa Scale and QUADAS-II tools. Study synthesis and assessment of the certainty of the evidence was performed using GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach. We included 28 systematic reviews and individual studies in this review. The GRADE certainty of evidence was low for the effectiveness of screening techniques and moderate to high for treatment efficacy. Antibody-detecting serological tests are the most effective screening tests for detection of both schistosomiasis and strongyloidiasis in low-endemicity settings, because they have higher sensitivity than conventional parasitological methods. Short courses of praziquantel and ivermectin were safe and highly effective and cost-effective in treating schistosomiasis and strongyloidiasis, respectively. Economic modelling suggests presumptive single-dose treatment of strongyloidiasis with ivermectin for all migrants is likely cost-effective, but feasibility of this strategy has yet to be demonstrated in clinical studies. The evidence supports screening and treatment for schistosomiasis and strongyloidiasis in migrants from endemic countries, to reduce morbidity and mortality.

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