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The effectiveness and safety of X-PDT for cutaneous squamous cell carcinoma and melanoma

Authors
  • Shi, Lei1
  • Liu, Pei1
  • Wu, Jing2
  • Ma, Lun3
  • Zheng, Han3
  • Antosh, Michael P4, 5
  • Zhang, Haiyan1
  • Wang, Bo1
  • Chen, Wei3
  • Wang, Xiuli1
  • 1 Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, 200443, PR China
  • 2 Department of Computer Science & Statistics, University of Rhode Island, 9 Greenhouse Rd, Kingston, RI 02881, USA
  • 3 Department of Physics, the University of Texas at Arlington, Arlington, TX 76019-0059, USA
  • 4 Physics Department, University of Rhode Island, 2 Lippitt Rd, Kingston, RI 02881, USA
  • 5 Institute for Brain & Neural Systems, Brown University, 184 Hope St, Providence, RI 02912, USA
Type
Published Article
Journal
Nanomedicine
Publisher
Future Medicine
Publication Date
Jun 05, 2019
Volume
14
Issue
15
Pages
2027–2043
Identifiers
DOI: 10.2217/nnm-2019-0094
PMID: 31165659
PMCID: PMC7006790
Source
PubMed Central
Keywords
License
Unknown

Abstract

Aim: To clarify the effectiveness and safety of x-ray-activated photodynamic therapy (X-PDT) for cutaneous squamous cell carcinoma (SCC) and melanoma. Materials & methods: Copper-cysteamine nanoparticles were used as a photosensitizer of X-PDT. The dark toxicity and cytotoxicity were studied in vitro. Tumor volume, microvessel density and acute toxicity of mice were evaluated in vivo . Results: Without x-ray irradiation, copper-cysteamine nanoparticles were nontoxic for keratinocyte cells. XL50 cells (SCC) were more sensitive to X-PDT than B16F10 cells (melanoma). X-PDT successfully inhibited the growth of SCC in vivo (p < 0.05), while the B16F10 melanoma was resistant. Microvessel density in SCC tissue was remarkably reduced (p < 0.05). No obvious acute toxicity reaction was observed. Conclusion: X-PDT is a safe and effective treatment for SCC.

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