Affordable Access

Access to the full text

The effectiveness and safety of traditional Chinese herbal medicine for the treatment of male infertility associated with sperm DNA fragmentation

Authors
  • Li, Qingrui1
  • Zhang, Chao1
  • Li, Chenxi2
  • Lin, Xuyao2
  • Wang, Mingkai2
  • Wu, Lin2
  • Li, Hua2
  • Ye, Pule2
  • Qin, Guozheng3
  • 1 Beijing University of Chinese Medicine, Beijing
  • 2 Yunnan University of Traditional Chinese Medicine
  • 3 Hospital of Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan, China.
Type
Published Article
Journal
Medicine
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Mar 05, 2021
Volume
100
Issue
9
Identifiers
DOI: 10.1097/MD.0000000000024918
PMID: 33655953
PMCID: PMC7939154
Source
PubMed Central
Keywords
License
Green

Abstract

Background: Sperm DNA fragmentation (SDF) may hinder embryonic development and growth, increasing the risk of spontaneous miscarriage, and is considered an important factor affecting male infertility (MI). Traditional Chinese herbal medicine is considered effective in the treatment of MI due to SDF by nourishing kidney essence or promoting blood circulation for removing blood stasis. The objective of this systematic review protocol is to evaluate the effectiveness and safety of traditional Chinese herbal medicine on the treatment of MI associated with SDF. Methods: We searched the PubMed, Embase, Web of Science, Cochrane Library, CNKI, VIP Chinese Science, Technology Journal Database, and Wanfang Database until the end of 2020 for English and Chinese published literature. Randomized controlled trials (RCTs) to evaluate the effectiveness and safety of traditional Chinese herbal medicine for the treatment of MI associated with SDF will be included. Study selection and data extraction were performed independently by 2 reviewers, and the quality evaluation and risk assessment were assessed by the Cochrane collaboration's tool, and use the RevMan 5.3 software for meta-analysis. Conclusion: This study will evaluate the efficacy and safety of traditional Chinese herbal medicine for the treatment of MI due to SDF, which may provide some help for the clinician's decision. Prospero registration number: CRD42020221053.

Report this publication

Statistics

Seen <100 times