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Effectiveness and safety of reduced-dose telaprevir-based triple therapy in chronic hepatitis C patients.

Authors
  • Sezaki, Hitomi
  • Suzuki, Fumitaka
  • Hosaka, Tetsuya
  • Akuta, Norio
  • Fukushima, Taito
  • Hara, Tasuku
  • Kawamura, Yusuke
  • Kobayashi, Masahiro
  • Suzuki, Yoshiyuki
  • Saitoh, Satoshi
  • Arase, Yasuji
  • Ikeda, Kenji
  • Kumada, Hiromitsu
Type
Published Article
Journal
Hepatology research : the official journal of the Japan Society of Hepatology
Publication Date
Oct 01, 2014
Volume
44
Issue
10
Identifiers
DOI: 10.1111/hepr.12268
PMID: 24397402
Source
Medline
Keywords
License
Unknown

Abstract

Compared to triple therapy including telaprevir 2250 mg/day, that including telaprevir at a reduced dose of 1500 mg/day was associated with lower rates of anemia and similar antiviral efficacy. Such a regimen may meaningfully improve sustained virological response rates, especially among female and elderly Japanese patients.

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