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The effectiveness of oral tin mesoporphyrin prophylaxis in reducing bilirubin production after an oral heme load in a transgenic mouse model.

Authors
  • DeSandre, Glenn H
  • Wong, Ronald J
  • Morioka, Ichiro
  • Contag, Christopher H
  • Stevenson, David K
Type
Published Article
Journal
Biology of the neonate
Publication Date
Jan 01, 2006
Volume
89
Issue
3
Pages
139–146
Identifiers
PMID: 16205054
Source
Medline
License
Unknown

Abstract

A single oral dose of SnMP results in durable inhibition of bilirubin production and HO activity for at least 24 h in a mouse model of oral heme loading. Further studies are needed to fully elucidate the duration of this protection against hyperbilirubinemia due to a delayed heme load and any long-term consequences of prophylaxis with SnMP on HO-1 transcription and HO-1 protein.

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