Background The purpose of this study was to determine the effectiveness of mindfulness-based art therapy (MBAT) in promoting life style in Iranian menopausal women. Methods This study was a quasi experimental study that was conducted on 104 menopausal women in Neyshabur,Iran 2018. One hundred and four menopausal women completed both the pre- and post-study measurements. The MBAT group demonstrated a significant decrease in symptoms of distress and significant improvements in key aspects of the health-related style of life (as measured by HPLPII questionnaire). Results The MBAT interventions had a significant effect on improving lifestyle behaviors (p < 0.05). Among the dimensions of style of life, the highest mean score was for nutrition (35.14 ± 3.35), and the lowest score was achieved by the subdomains of physical activity (14.89 ± 3.55). The mean (standard deviation) scores of stress management, interpersonal relations and health responsibility were 21.54 ± 1.12, 26.00 ± 2.54 and 16.87 ± 4.10, respectively. Conclusion This investigation of MBAT provides initial encouraging data that support a possible future role for the intervention as a psychosocial option for decrease in symptoms of distress menopausal women and improve lifestyle.