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Effectiveness and limitations of the use of the gonadotropin-releasing hormone agonist leuprolide acetate in the diagnosis of delayed puberty in males.

Authors
  • Lanes, R
  • Gunczler, P
  • Osuna, J A
  • Palacios, A
  • Carrillo, E
  • Ramirez, X
  • Garcia, C
  • Paoli, M
  • Villaroel, O
Type
Published Article
Journal
Hormone research
Publication Date
Jan 01, 1997
Volume
48
Issue
1
Pages
1–4
Identifiers
PMID: 9195202
Source
Medline
License
Unknown

Abstract

In order to evaluate the effectiveness of the gonadotropin-releasing hormone agonist leuprolide acetate in distinguishing gonadotropin deficiency from delayed puberty, a single subcutaneous dose of 20 micrograms/kg of leuprolide acetate was administered at 07.00 h to 14 patients with constitutionally delayed puberty and to 8 gonadotropin-deficient subjects, and serum gonadotropin and testosterone levels were determined at baseline and 1,2,3,6,12, and 24 h thereafter. The increase in gonadotropin and testosterone levels was significant in patients with delayed puberty, so that the mean peak luteinizing hormone and to a lesser degree the mean peak testosterone levels clearly differentiated normally delayed from gonadotropin-deficient puberty. However, when the peak gonadotropin and testosterone concentrations were analyzed individually, there was a considerable overlap between the two groups of males, limiting the usefulness of this test.

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