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Effectiveness of Adjunctive Analgesics in Head and Neck Cancer Patients Receiving Curative (Chemo-) Radiotherapy: A Systematic Review.

Authors
  • Lefebvre, Tessa1, 2
  • Tack, Laura1
  • Lycke, Michelle1
  • Duprez, Fréderic2
  • Goethals, Laurence3
  • Rottey, Sylvie4
  • Cool, Lieselot1
  • Van Eygen, Koen5
  • Stubbs, Brendon6
  • Schofield, Patricia7
  • Pottel, Hans8
  • Boterberg, Tom2
  • Debruyne, Philip1, 6
  • 1 Department of Medical Oncology, Kortrijk Cancer Centre, General Hospital Groeninge, Kortrijk, Belgium. , (Belgium)
  • 2 Department of Radiation Oncology, Ghent University Hospital, Ghent, Belgium. , (Belgium)
  • 3 Department of Radiotherapy, Kortrijk Cancer Centre, General Hospital Groeninge, Kortrijk, Belgium. , (Belgium)
  • 4 Department of Medical Oncology, Ghent University Hospital, Ghent, Belgium. , (Belgium)
  • 5 Department of Haematology, Kortrijk Cancer Centre, General Hospital Groeninge, Kortrijk, Belgium. , (Belgium)
  • 6 Positive Ageing Research Institute (PARI), Faculty of Health, Education, Medicine and Social Care, Anglia Ruskin University, Chelmsford, UK.
  • 7 Sheffield Hallam University, Sheffield, UK.
  • 8 Department of Public Health and Primary Care @ Kulak, Catholic University Leuven Kulak, Kortrijk, Belgium. , (Belgium)
Type
Published Article
Journal
Pain medicine (Malden, Mass.)
Publication Date
Feb 04, 2021
Volume
22
Issue
1
Pages
152–164
Identifiers
DOI: 10.1093/pm/pnaa044
PMID: 32219435
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Our aim was to give an overview of the effectiveness of adjunctive analgesics in head and neck cancer (HNC) patients receiving (chemo-) radiotherapy. Systematic review. This systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. PubMed, Embase, Web of Science, the Cochrane Library, and ClinicalTrials.gov were searched for studies concerning "head neck cancer," "adjunctive analgesics," "pain," and "radiotherapy." Pain outcome, adverse events, and toxicity and other reported outcomes, for example, mucositis, quality of life, depression, etc. Nine studies were included in our synthesis. Most studies were of low quality and had a high risk of bias on several domains of the Cochrane Collaboration tool. Only two studies comprised high-quality randomized controlled trials in which pregabalin and a doxepin rinse showed their effectiveness for the treatment of neuropathic pain and pain from oral mucositis, respectively, in HNC patients receiving (chemo-) radiotherapy. More high-quality trials are necessary to provide clear evidence on the effectiveness of adjunctive analgesics in the treatment of HNC (chemo-) radiation-induced pain. © The Author(s) 2020. Published by Oxford University Press on behalf of the American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: [email protected]

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