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Effectiveness of absorption and passage through the small intestine, as a model of oral prolactin administration.

Authors
  • Dolińska, Barbara1
  • Siemiradzka, Wioletta2
  • Ryszka, Florian3
  • 1 Department of Pharmaceutical Technology, Medical University of Silesia in Katowice, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Poland; "Biochefa" Pharmaceutical Research and Production Plant, Poland. , (Poland)
  • 2 Department of Pharmaceutical Technology, Medical University of Silesia in Katowice, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Poland. Electronic address: [email protected] , (Poland)
  • 3 "Biochefa" Pharmaceutical Research and Production Plant, Poland. , (Poland)
Type
Published Article
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Publication Date
Oct 07, 2019
Volume
120
Pages
109515–109515
Identifiers
DOI: 10.1016/j.biopha.2019.109515
PMID: 31600642
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The process of absorption and permeation of PRL through the small intestine of 1-day-old piglet from the different compositions of solutions prepared for oral administration was investigated. This was achieved by determining the effect of hormone concentration (0.25 mg / ml or 0.5 mg / ml or 0.75 mg / ml), the concentration of stabilizing substances - trehalose (6 mg / ml or 12 mg / ml or 18 mg / ml) and mannitol (6 mg / ml or 12 mg / ml or 18 mg / ml) and the pH of the solution (2.5 or 3.0 or 3.5) on the degree of absorption and permeation of the PRL. The conditions for the absorption and penetration of PRL from solutions of various compositions for oral administration through the natural membrane (small intestine of the 1-day-old sucking piglet) in the in vivo conditions were simulated. The studies used an in vivo model in which the enzymatic profile in the body is not yet fully developed (no pepsin). It was found that in the studied range the absorption of PRL in the small intestine of the 1-day-old sucking piglet is significantly related to the concentration of the hormone and trehalose in the solution from which it is absorbed. In contrast, all factors studied (hormone concentration, trehalose and mannitol concentration, pH value of the solution) influence the process of penetration of the PRL in the studied range. It was also found that the hormone concentration significantly influences the rate of its absorption and permeation (the fastest occurs at a concentration of 0.5 mg/mL). The results suggest possibility of oral prolactin administration in order to ensure proper growth, development and increase the resistance and survival of sucking piglets. Copyright © 2019 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

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