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Effective connectivity of the fronto-parietal network during attentional control.

Authors
  • Wang, Liang
  • Liu, Xun
  • Guise, Kevin G
  • Knight, Robert T
  • Ghajar, Jamshid
  • Fan, Jin
Type
Published Article
Journal
Journal of Cognitive Neuroscience
Publisher
MIT Press
Publication Date
Mar 01, 2010
Volume
22
Issue
3
Pages
543–553
Identifiers
DOI: 10.1162/jocn.2009.21210
PMID: 19301995
Source
Medline
License
Unknown

Abstract

The ACC, the dorsolateral prefrontal cortex (DLPFC), and the parietal cortex near/along the intraparietal sulcus (IPS) are members of a network subserving attentional control. Our recent study revealed that these regions participate in both response anticipation and conflict processing. However, little is known about the relative contribution of these regions in attentional control and how the dynamic interactions among these regions are modulated by detection of predicted versus unpredicted targets and conflict processing. Here, we examined effective connectivity using dynamic causal modeling among these three regions during a flanker task with or without a target onset cue. We compared various models in which different connections among ACC, DLPFC, and IPS were modulated by bottom-up stimulus-driven surprise and top-down conflict processing using Bayesian model selection procedures. The most optimal of these models incorporated contextual modulation that allowed processing of unexpected (surprising) targets to mediate the influence of the IPS over ACC and DLPFC and conflict processing to mediate the influence of ACC and DLPFC over the IPS. This result suggests that the IPS plays an initiative role in this network in the processing of surprise targets, whereas ACC and DLPFC interact with each other to resolve conflict through attentional modulation implemented via the IPS.

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