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Effect of withdrawal of somatostatin plus growth hormone (GH)-releasing hormone as a stimulus of GH secretion in Cushing's syndrome.

Authors
  • Leal-Cerro, Alfonso
  • Soto, Alfonso
  • Martínez, Maria Asunción
  • Alvarez, Paula
  • Isidro, Luisa
  • Casanueva, Felipe F
  • Dieguez, Carlos
  • Cordido, Fernando
Type
Published Article
Journal
Clinical endocrinology
Publication Date
Dec 01, 2002
Volume
57
Issue
6
Pages
745–749
Identifiers
PMID: 12460324
Source
Medline
License
Unknown

Abstract

This study has demonstrated a significantly blunted peak GH response to somatostatin infusion withdrawal plus GHRH in Cushing's syndrome patients. In this theoretical situation of decreased somatostatinergic tone there is persistence of GH hyposecretion in Cushing's syndrome, suggesting the existence of a pituitary defect responsible for the decreased GH secretion in Cushing's syndrome.

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