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The Effect of Whey Protein Supplementation on Myofibrillar Protein Synthesis and Performance Recovery in Resistance-Trained Men

Authors
  • Davies, Robert W.1, 2
  • Bass, Joseph J.1, 2, 3
  • Carson, Brian P.1, 2, 4
  • Norton, Catherine1, 2, 4
  • Kozior, Marta1, 2
  • Wilkinson, Daniel J.3
  • Brook, Matthew S.3
  • Atherton, Philip J.3
  • Smith, Ken3
  • Jakeman, Philip M.1, 2, 4
  • 1 (P.M.J.)
  • 2 & Immunity, University of Limerick, V94 T9PX Limerick, Ireland
  • 3 (K.S.)
  • 4 Health Research Institute (HRI), University of Limerick, V94 T9PX Ireland, Ireland
Type
Published Article
Journal
Nutrients
Publisher
MDPI AG
Publication Date
Mar 21, 2020
Volume
12
Issue
3
Identifiers
DOI: 10.3390/nu12030845
PMID: 32245197
PMCID: PMC7146144
Source
PubMed Central
Keywords
License
Green

Abstract

Background: The aim of this study was to investigate the effect of whey protein supplementation on myofibrillar protein synthesis (myoPS) and muscle recovery over a 7-d period of intensified resistance training (RT). Methods: In a double-blind randomised parallel group design, 16 resistance-trained men aged 18 to 35 years completed a 7-d RT protocol, consisting of three lower-body RT sessions on non-consecutive days. Participants consumed a controlled diet (146 kJ·kg−1·d−1, 1.7 g·kg−1·d−1 protein) with either a whey protein supplement or an isonitrogenous control (0.33 g·kg−1·d−1 protein). To measure myoPS, 400 ml of deuterium oxide (D2O) (70 atom %) was ingested the day prior to starting the study and m. vastus lateralis biopsies were taken before and after RT-intervention. Myofibrillar fractional synthetic rate (myoFSR) was calculated via deuterium labelling of myofibrillar-bound alanine, measured by gas chromatography-pyrolysis-isotope ratio mass spectrometry (GC-Pyr-IRMS). Muscle recovery parameters (i.e., countermovement jump height, isometric-squat force, muscle soreness and serum creatine kinase) were assessed daily. Results: MyoFSR PRE was 1.6 (0.2) %∙d−1 (mean (SD)). Whey protein supplementation had no effect on myoFSR ( p = 0.771) or any recovery parameter ( p = 0.390–0.989). Conclusions: Over an intense 7-d RT protocol, 0.33 g·kg−1·d−1 of supplemental whey protein does not enhance day-to-day measures of myoPS or postexercise recovery in resistance-trained men.

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