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Effect of vanadium on L-ascorbic acid concentration in rat tissues.

Authors
Type
Published Article
Journal
General Pharmacology The Vascular System
0306-3623
Publisher
Elsevier
Publication Date
Volume
25
Issue
3
Pages
467–470
Identifiers
PMID: 7926592
Source
Medline

Abstract

1. Two-month old Wistar rats of both sexes received, as sole drinking liquid, an aqueous solution of ammonium metavanadate (AMV) at a concentration of 0.01, 0.05, 0.15 and 0.30 mg V/ml (corresponding to 0.2, 1, 3 and 6 mM solution) over 4 weeks. 2. In the animal groups receiving AMV solution of 0.15 or 0.30 mg V/ml concentrations to drink, a statistically significant decrease of the uptake of food and AMV solution was observed, as compared with food and water taken up in the same time by the control group. 3. Moreover, a distinct decrease of the L-ascorbic acid level was noted in the liver, kidneys, spleen and adrenals. These differences proved statistically significant in single cases of animals receiving a solution of 0.05 and 0.15 mg V/ml concentration and in all animals given the solution at the highest vanadium concentration.

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