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Effect of UV Light on RNA-Directed DNA Polymerase Activity of Murine Oncornaviruses.

Authors
  • Lovinger, G G
  • Ling, H P
  • Gilden, R V
  • Hatanaka, M
Type
Published Article
Journal
Journal of virology
Publication Date
May 01, 1975
Volume
15
Issue
5
Pages
1273–1275
Identifiers
PMID: 16789159
Source
Medline
License
Unknown

Abstract

The UV inactivation of RNA-directed DNA polymerase activity of Rauscher leukemia virus was shown to be due to damage to the protein. The UV dose resulting in 37% survival of viral polymerase activity at 254 nm was 2.4 x 10(4) to 3.1 x 10(4) ergs/mm(2). The inactivation rate of p30, a major internal viral protein, was much slower.

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