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Effect of type I interferon(s) on cell viability and apoptosis in primary human thyrocyte cultures.

Authors
  • Caraccio, Nadia
  • Cuccato, Sabina
  • Pratesi, Federico
  • Dardano, Angela
  • Ursino, Silvia
  • Chimenti, Daniele
  • Boldrini, Laura
  • Materazzi, Gabriele
  • Migliorini, Paola
  • Monzani, Fabio
Type
Published Article
Journal
Thyroid
Publisher
Mary Ann Liebert
Publication Date
Feb 01, 2009
Volume
19
Issue
2
Pages
149–155
Identifiers
DOI: 10.1089/thy.2008.0290
PMID: 19191746
Source
Medline
License
Unknown

Abstract

Both type I IFN(s) increase apoptosis in primary thyrocyte cultures, but only IFN-beta modulates FAS and Bcl-2 gene expression toward a proapoptotic pathway. Because apoptosis plays an important role in thyroid homeostasis and disease, this mechanism may contribute to the development and progression of type I IFN(s) therapy-associated thyroid disease.

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