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Effect of troxerutin and methionine on spin trapping of free oxy-radicals.

Authors
Type
Published Article
Journal
Biomedica biochimica acta
Publication Date
Volume
47
Issue
10-11
Identifiers
PMID: 2907855
Source
Medline

Abstract

The cardioprotective agents troxerutin and methionine are radical scavengers and compete with the DMPO adduct formation of .OH generated by the Fenton reaction. The concentration of trapped .O2- generated by the xanthine oxidase/hypoxanthine reaction is lowered in the presence of troxerutin. The decay of DMPO-OH is decreased by troxerutin compared to the control. In the presence of methionine a carbon-centered radical is produced. The investigations support the opinion that the scavenging of oxygen derived free radicals is of importance for the cardioprotective action of these agents.

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