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Effect of tri-iodothyronine on protein turnover in rat hepatocyte primary cultures.

Authors
  • Gallo, G
  • Voci, A
  • Schwarze, P E
  • Fugassa, E
Type
Published Article
Journal
The Journal of endocrinology
Publication Date
May 01, 1987
Volume
113
Issue
2
Pages
173–177
Identifiers
PMID: 3585230
Source
Medline
License
Unknown

Abstract

The effect of tri-iodothyronine (T3) on protein turnover was studied using primary cultures of rat hepatocytes. Protein synthesis was significantly stimulated in cells cultured for 6 days in the presence of T3 (1 mumol/l). Protein secretion into the culture medium was not affected by the hormone. Breakdown of long-lived proteins, the bulk of cellular proteins which are preferentially degraded through the autophagic lysosomal pathway, was significantly stimulated by the hormone. It is concluded that T3 elicits a general stimulation of protein turnover in cultured hepatocytes.

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