Affordable Access

deepdyve-link
Publisher Website

The effect of trapidil and bevacizumab on tracheal anastomotic wound healing.

Authors
  • Ertan, Esra1
  • Göçer, Perihan2
  • Naycı, Ali3
  • Cömelekoğlu, Ulkü4
  • Atış, Sibel5
  • Bozdağan Arpacı, Rabia6
  • Ersöz, Gülden7
  • Körlü, Savaş8
  • Umit Talas, Derya8
  • 1 Yedikule Chest Disease Hospital, Istanbul, Turkey. , (Turkey)
  • 2 Mersin University Faculty of Medicine, Mersin, Turkey. , (Turkey)
  • 3 Mersin University Faculty of Medicine, Pediatric Surgery, Mersin, Turkey. , (Turkey)
  • 4 Mersin University Faculty of Medicine, Biophysic Department, Mersin, Turkey. , (Turkey)
  • 5 Mersin University Faculty of Medicine, Chest Disease Department, Mersin, Turkey. , (Turkey)
  • 6 Mersin University Faculty of Medicine, Pathology Department, Mersin, Turkey. , (Turkey)
  • 7 Mersin University Faculty of Medicine, Infectious Disease Department, Mersin, Turkey ; Mersin University Faculty of Medicine, Ear Nose Throat Department, Mersin, Turkey. , (Turkey)
  • 8 Mersin University Faculty of Medicine, Ear Nose Throat Department, Mersin, Turkey. , (Turkey)
Type
Published Article
Journal
Current Therapeutic Research
Publisher
Elsevier
Publication Date
Dec 01, 2013
Volume
75
Pages
5–7
Identifiers
DOI: 10.1016/j.curtheres.2013.04.002
PMID: 24465035
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Although bevacizumab has deleterious effects on the healing of colonic anastomoses, trapidil improves wound healing of colonic and tracheal anastomoses. We aimed to assess the effects of bevacizumab and trapidil on wound healing after tracheal transection. We evaluated 35 rats divided in 5 groups: bevacizumab (Group I, n = 7), trapidil (Group II, n = 7), trapidil + bevacizumab (Group III, n = 7), controls (Group IV, n = 7), and sham (Group V, n = 7). Anastomotic healing was assessed by measurement of bursting pressure and inflammation score at the anastomotic region on the seventh day. The bursting pressures of Group II, Group III, and Group V were significantly higher than controls (P = 0.001, P = 0.033, and P = 0.035, respectively). Fibrosis was significantly high in the sham group when compared with the other four groups (P = 0.047). Although bevacizumab seems to impair anastomotic healing, trapidil can be suggested to improve tracheal anastomoses.

Report this publication

Statistics

Seen <100 times