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Effect of trabeculectomy on corneal endothelial cell loss.

Authors
  • Hirooka, Kazuyuki1
  • Nitta, Eri2
  • Ukegawa, Kaori2
  • Sato, Shino2
  • Kiuchi, Yoshiaki3
  • 1 Ophthalmology and Visual Science, Hiroshima University, Hiroshima, Japan [email protected] , (Japan)
  • 2 Ophthalmology, Kagawa University, Miki, Japan. , (Japan)
  • 3 Ophthalmology and Visual Science, Hiroshima University, Hiroshima, Japan. , (Japan)
Type
Published Article
Journal
British Journal of Ophthalmology
Publisher
BMJ
Publication Date
Mar 01, 2020
Volume
104
Issue
3
Pages
376–380
Identifiers
DOI: 10.1136/bjophthalmol-2018-313417
PMID: 31201168
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

To investigate changes in corneal endothelial cell density (CECD) after trabeculectomy. This prospective, observational study followed 117 eyes of 117 patients for 2 years after trabeculectomy. The central cornea was examined by corneal specular microscopy prior to and at every 6 months after the surgery. Survival analysis of patients who exhibited a 10% or less reduction of the postoperative CECD compared with preoperative levels was assessed using the Kaplan-Meier survival curve. A Cox proportional hazards model was used to evaluate prognostic factors for decreasing CECD. At baseline, the mean CECD was 2420±357 cells/mm2, while at 6, 12, 18 and 24 months after surgery, the mean CECD was 2324±373 cells/mm2 (p<0.001), 2276±400 cells/mm2 (p<0.001), 2290±398 cells/mm2 (p<0.001) and 2267±446 cells/mm2 (p<0.001), respectively. At 6, 12, 18 and 24 months after surgery, the results of the Kaplan-Meier survival analysis of the 10% loss of CECD from baseline were 91%, 85%, 83% and 77%, respectively. Uveitic glaucoma was a significant prognostic factor for decreasing CECD (p=0.041). CECD significantly and continuously decreased after trabeculectomy. © Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.

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