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Effect of toxin A and B of Clostridium difficile on rabbit ileum and colon.

Authors
  • Mitchell, T J
  • Ketley, J M
  • Haslam, S C
  • Stephen, J
  • Burdon, D W
  • Candy, D C
  • Daniel, R
Type
Published Article
Journal
Gut
Publication Date
Jan 01, 1986
Volume
27
Issue
1
Pages
78–85
Identifiers
PMID: 3949240
Source
Medline
License
Unknown

Abstract

The effect of purified toxin A and partially purified toxin B on rabbit ileum and colon was investigated. Toxin A caused tissue damage which was followed by permeability changes and fluid accumulation in both tissues. Toxin A did not increase the permeability of the colon to the extent observed for ileum; secreted fluid contained less protein of plasma origin. Toxin B had no effect on either tissue. Secretory and tissue damaging properties of crude C difficile toxins were found to be due to toxin A.

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