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Effect on tissue vitamin A levels in the rat following subchronic exposure to four individual PCB congeners (IUPAC 77, 118, 126, and 153).

Authors
  • Håkansson, H
  • Manzoor, E
  • Trossvik, C
  • Ahlborg, U G
  • Chu, I
  • Villenueve, D
Type
Published Article
Journal
Chemosphere
Publisher
Elsevier
Publication Date
Jan 01, 1994
Volume
29
Issue
9-11
Pages
2309–2313
Identifiers
PMID: 7850379
Source
Medline
License
Unknown

Abstract

The present study was carried out to investigate the effect on tissue vitamin A levels in rats exposed to 3,3',4,4'-tetraCB (CB-77), 2,3',4,4',5-pentaCB (CB-118), 3,3',4,4',5-pentaCB (CB-126), and 2,2',4,4',5,5'-hexaCB (CB-153). The obtained results show that hepatic vitamin A levels are reduced both in male and female rats following dietary exposure to individual PCB congeners for 13 weeks. However, there are pronounced potency differences between congeners. Compared to TCDD, the hepatic vitamin A reducing potencies of CB-126, CB-77 and CB-153, are 0.05, 0.0001 and 0.00001, respectively, in male rats. Compared to male rats, female rats are equally sensitive to hepatic vitamin A reduction both by TCDD and dioxinlike CBs. Effects on renal and pulmonary vitamin A levels vary between CBs and between sexes.

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