Affordable Access

deepdyve-link
Publisher Website

Is there an effect of thyroid autoimmunity on the outcomes of assisted reproduction?

Authors
  • Sakar, M N1
  • Unal, A2
  • Atay, A E3
  • Zebitay, A G2
  • Verit, F F2
  • Demir, S4
  • Turfan, M5
  • Omer, B6
  • 1 a Department of Obstetrics and Gynecology , Diyarbakir Gazi Yasargil Training and Research Hospital , Diyarbakir , Turkey.
  • 2 b Department of Obstetrics and Gynecology , Suleymaniye Maternity Training and Research Hospital , Istanbul , Turkey.
  • 3 c Department of Internal Medicine , Bagcilar Training and Research Hospital , Istanbul , Turkey.
  • 4 d Department of Obstetrics and Gynecology , Haseki Training and Research Hospital , Istanbul , Turkey.
  • 5 e Department of Microbiology , Suleymaniye Maternity Training and Research Hospital , Istanbul , Turkey.
  • 6 f Department of Biochemistry , School of Medicine, Istanbul University , Istanbul , Turkey.
Type
Published Article
Journal
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
Publication Date
2016
Volume
36
Issue
2
Pages
213–217
Identifiers
DOI: 10.3109/01443615.2015.1049253
PMID: 26492218
Source
Medline
Keywords
License
Unknown

Abstract

We aimed to evaluate the role of thyroid autoantibodies (TAA) on the outcomes of intracytoplasmic sperm injection-embryo transfer (ICSI-ET). A prospective case-control study was conducted in the in vitro fertilisation (IVF) centre of Suleymaniye Maternity Training and Research Hospital, Istanbul, Turkey between July 2013 and March 2014. A total of 49 (19.52%) TAA-positive and 202 TAA-negative patients were enrolled. Demographic characteristics and laboratory parameters were recorded. All patients underwent ICSI-ET. Thirty-one TAA-positive patients (32 cycles) and 121 TAA-negative patients (126 cycles) completed the study. Mean female age, body mass index (BMI), type of infertility, duration of infertility, antral follicle count (AFC), anti-Müllerian hormone (AMH), basal follicle stimulating hormone (bFSH), luteinising hormone (bLH), and oestradiol (bE2), prolactin and thyroid hormone profiles, male age and aetiology of infertility of both groups were similar (p > 0.05). There was no significant difference between groups in terms of duration and dose of gonadotropin (Gn) therapy, day of human chorionic Gn (hCG) administration, serum E2 and progesterone levels, number of collected oocytes, ratio of fertilisation, number of available embryos, positive pregnancy test, biochemical pregnancy, clinical pregnancy, ratio of miscarriage and ongoing pregnancy (p > 0.05). In conclusion, we failed to demonstrate a significant role of TAA on the outcomes of ICSI-ET in euthyroid patients. Further studies with larger numbers of participants are required to clarify these data.

Report this publication

Statistics

Seen <100 times