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Effect of theophylline on exercise-induced myocardial ischaemia.

Authors
  • Crea, F
  • Pupita, G
  • Galassi, A R
  • el Tamimi, H
  • Kaski, J C
  • Davies, G J
  • Maseri, A
Type
Published Article
Journal
Lancet (London, England)
Publication Date
Apr 01, 1989
Volume
1
Issue
8640
Pages
683–686
Identifiers
PMID: 2564505
Source
Medline
License
Unknown

Abstract

In a single-blind, placebo-controlled, randomised trial in 20 patients with stable angina pectoris, intravenous theophylline ethylenediamine (aminophylline), 7 mg/kg, increased the time to onset of angina by 46%, the heart-rate/blood-pressure product (an index of myocardial oxygen consumption) at 1 mm ST segment depression by 22%, and exercise duration by 24%. In a subsequent double-blind placebo-controlled trial in 8 patients a single oral dose of theophylline (375 mg) increased the time to onset of angina by 56%, the heart-rate/blood-pressure product at 1 mm ST segment depression by 22%, and the exercise duration by 35%. Infusion of theophylline ethylenediamine during angiography (10 patients) did not affect the diameter of epicardial coronary arteries. The beneficial effects of theophylline may be due to redistribution of coronary blood flow from non-ischaemic to ischaemic myocardium.

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