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Effect of Teriflunomide and Dimethyl Fumarate on Cortical Atrophy and Leptomeningeal Inflammation in Multiple Sclerosis: A Retrospective, Observational, Case-Control Pilot Study

Authors
  • Zivadinov, Robert
  • Bergsland, Niels
  • Carl, Ellen
  • Ramasamy, Deepa P.
  • Hagemeier, Jesper
  • Dwyer, Michael G.
  • Lizarraga, Alexis A.
  • Kolb, Channa
  • Hojnacki, David
  • Weinstock-Guttman, Bianca
Publication Date
Mar 12, 2019
Source
MDPI
Keywords
Language
English
License
Green
External links

Abstract

3.12%, p = 0.015) months. No significant differences were found between the TFM and DMF groups in the frequency and number of LMCE foci over the follow-up. TFM showed a numerically lower rate of whole brain atrophy over 24 months (p = 0.077), compared to DMF. No significant clinical or MRI lesion differences between TFM and DMF were detected over follow-up. Conclusions: These findings suggest that TFM has a superior effect on the preservation of cortical GM volume, compared to DMF.

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