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Effect of streptozotocin diabetes on gingivitis in plaque-susceptible rats.

Authors
Type
Published Article
Journal
Journal of dental research
Publication Date
Volume
65
Issue
1
Pages
49–52
Identifiers
PMID: 3455698
Source
Medline
License
Unknown

Abstract

The periodontal pocket probing depths of mandibular incisors of plaque-susceptible (Sus) rats, which spontaneously exhibit gingivitis with accumulation of plaque, were increased 20 days after injection of streptozotocin (70 mg/kg, i.v.). The accumulated plaque weights were also increased in Sus rats with streptozotocin diabetes, and a positive correlation was found between the plaque weights and the pocket depths. Histological findings showed that this inflammatory reaction in gingival tissue was higher and more extensive in diabetic Sus rats than in control Sus rats. These findings suggest that the accumulated plaque is the important factor for the severe breakdown of gingival tissue in this experimental model.

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