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Effect of Spirulina fusiformis on cyclophosphamide and mitomycin-C induced genotoxicity and oxidative stress in mice.

Authors
  • Premkumar, K
  • Pachiappan, A
  • Abraham, S K
  • Santhiya, S T
  • Gopinath, P M
  • Ramesh, A
Type
Published Article
Journal
Fitoterapia
Publisher
Elsevier
Publication Date
Dec 01, 2001
Volume
72
Issue
8
Pages
906–911
Identifiers
PMID: 11731115
Source
Medline
License
Unknown

Abstract

Spirulina fusiformis was tested for its possible in vivo protective effects against cyclophosphamide (CP) and mitomycin-C (MMC) induced genotoxicity and oxidative stress in mice. Pre-treatment with S. fusiformis (250, 500 and 1000 mg kg(-1), p.o., daily for 5 days) significantly reduced the chromosomal damage and lipid peroxidation with concomitant changes in antioxidants and detoxification systems. All the three tested doses were effective in exerting a protective effect against CP and MMC.

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