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Effect of sophoridine on dextran sulfate sodium-induced colitis in C57BL/6 mice.

Authors
  • Zhao, Wen-Chang
  • Song, Li-Jun
  • Deng, Hong-Zhu
Type
Published Article
Journal
Journal of Asian natural products research
Publication Date
Nov 01, 2010
Volume
12
Issue
11
Pages
925–933
Identifiers
DOI: 10.1080/10286020.2010.505188
PMID: 21061213
Source
Medline
License
Unknown

Abstract

Sophoridine (SRI), one of the quinolizidine alkaloids, is a new anticancer drug with noticeable antitumor action and lower toxicity. To our knowledge, there is no report about its effect on colitis. Repeated colitis was induced by administration of four cycles of 4% DSS. The severity of colitis was assessed on the basis of clinical signs, colon length and histology scores. Moreover, cecum secretory immunoglobulin A (sIgA) and plasma haptoglobin (HP) were analyzed by enzyme-linked immunosorbent assay and ICAM-1, and macrophage migration inhibitory factor (MIF) gene expression was analyzed by quantitative reverse transcriptase real-time polymerase chain reaction using SYBR Green I. SRI administration significantly attenuated the damage and caused substantial reduction of the rise in plasma HP, and maintained the level of cecum sIgA. SRI inhibited the ICAM-1 gene expression and had no effect on MIF gene expression. In conclusion, for the first time, the activity of SRI on DSS-induced colitis mice was investigated, which suggests that SRI could be an attractive therapeutic option in the treatment of inflammatory bowel disease.

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