Affordable Access

Effect of some cardiac and respiratory drugs on succinate-cytochrome c reductase.

Authors
  • Balbaa, Mahmoud
  • Al-Meer, Jehan
  • Al-Khal, Amina
Type
Published Article
Journal
Journal of enzyme inhibition and medicinal chemistry
Publication Date
Aug 01, 2004
Volume
19
Issue
4
Pages
343–347
Identifiers
PMID: 15558951
Source
Medline
License
Unknown

Abstract

Succinate-cytochrome c reductase was inhibited in vitro and in vivo by phenobarbitone, aminophylline and neostigmine using both 2,6-dichlorophenolindophenol (DCIP) and cytochrome c (cyt c) as substrates. The enzyme was also activated by gallamine towards both substrates. In vitro, phenobarbitone and aminophylline inhibited the enzyme with respect to the reduction of DCIP and cyt c in a non-competitive manner with Ki values of 1.5 x 10(-5) and 5.7 x 10(-5)M, respectively. Moreover, neostigmine competitively inhibited the enzyme towards both substrates with Ki values of 1.36 x 10(-5) and 1.50 x 10(-5)M, respectively.

Report this publication

Statistics

Seen <100 times