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The effect of solvent quality on pathway-dependent solution-state self-assembly of an amphiphilic diblock copolymer

Authors
  • Venkataraman, Shrinivas1
  • Wei, Guangmin2
  • Mineart, Kenneth P.2
  • Hedrick, James L.3
  • Prabhu, Vivek M.2
  • Yang, Yi Yan1
  • 1 Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669
  • 2 Material Measurement Laboratory, National Institute of Standards and Technology, 100 Bureau Drive, Gaithersburg, Maryland 20899, USA
  • 3 IBM Almaden Research Center, 650 Harry Road, San Jose, California 95120, USA
Type
Published Article
Journal
Journal of Applied Physics
Publisher
American Institute of Physics
Publication Date
Jan 01, 2020
Volume
127
Issue
12
Pages
125104–125104
Identifiers
PMID: 33041365
PMCID: PMC7543663
Source
PubMed Central
Disciplines
  • Article
License
Unknown

Abstract

The cholesterol-functionalized polycarbonate-based diblock copolymer, PEG113- b -P(MTC-Chol)30, forms pathway-dependent nanostructures via dialysis-based solvent exchange. The initial organic solvent that dissolves or disperses the polymer dictates a self-assembly pathway. Depending upon the initial solvent, nanostructures of disk-like micelles, exhibiting asymmetric growth and hierarchical features, are accessible from a single amphiphilic precursor. Dioxane and tetrahydrofuran (THF) molecularly dissolve the block copolymer, but THF yields disks, while dioxane yields stacked disks after dialysis against water. Dimethylformamide and methanol display dispersed disks and then form stacked disk structures after dialysis. The path-dependent morphology was correlated to solubility parameters, an understanding of which offers routes to tailor self-assemblies with limited sets of building blocks.

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