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Effect of soil microbial feeding on gut microbiome and cadmium toxicity in Caenorhabditis elegans.

Authors
  • Lee, Seungbaek1
  • Kim, Youngho1
  • Choi, Jinhee2
  • 1 School of Environmental Engineering, University of Seoul, 163 Seoulsiripdae-ro, Dongdaemun-gu, Seoul, 02504, Republic of Korea. , (North Korea)
  • 2 School of Environmental Engineering, University of Seoul, 163 Seoulsiripdae-ro, Dongdaemun-gu, Seoul, 02504, Republic of Korea. Electronic address: [email protected] , (North Korea)
Type
Published Article
Journal
Ecotoxicology and Environmental Safety
Publisher
Elsevier
Publication Date
Oct 26, 2019
Volume
187
Pages
109777–109777
Identifiers
DOI: 10.1016/j.ecoenv.2019.109777
PMID: 31670241
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Microbial community of an organism plays an important role on its fitness, including stress responses. In this study, we investigated the effect of the culturable subset of soil microbial community (SMB) on the stress response of the soil nematode Caenorhabditis elegans, upon exposure to one of the major soil contaminants, cadmium (Cd). Life history traits and the stress responses to Cd exposure were compared between SMB- and Escherichia coli strain OP50-fed worms. SMB-fed worms showed higher reproduction rates and longer lifespans. Also, the SMB-fed worms showed more tolerant response to Cd exposure. Gene expression profiling suggested that the chemical stress and immune response of worms were boosted upon SMB feeding. Finally, we investigated C. elegans gut microbial communities in the presence and absence of Cd in OP50- and SMB-fed C. elegans. In the OP50-fed worms, changes in microbial community by Cd exposure was severe, whereas in the SMB-fed worms, it was comparatively weak. Our results suggest that the SMB affects the response of C. elegans to Cd exposure and highlight the importance of the gut microbiome in host stress response. Copyright © 2019. Published by Elsevier Inc.

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