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The effect of sodium salicylate on acute Chagasic myocarditis in C3H mice.

Authors
Type
Published Article
Journal
The Journal of tropical medicine and hygiene
Publication Date
Volume
80
Issue
3
Pages
52–58
Identifiers
PMID: 406418
Source
Medline
License
Unknown

Abstract

In two separate experiments, six months apart, utilizing different controls and different methods, sodium salicylate in anti-inflammatory doses was administered by gavage to mice with acute Chagasic myocarditis (T. cruz) at the onset of parasitemia. Sodium citrate was used as a control. Animals given salicylate showed decreased blood trypanosome counts and myocardial pseudocyst formation, both absolutely and in the rates of formation. Decreased inflammation and necrosis were associated with salicylate therapy. Survival of the animals was not increased by treatment. The effects cannot be explained by sodium ion concentration, the technique of gavage, or any factor except the presence of salicylate ion.

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