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The effect of serum lithium levels on renal function in geriatric outpatients: a retrospective longitudinal study.

Authors
  • Rej, Soham
  • Looper, Karl
  • Segal, Marilyn
Type
Published Article
Journal
Drugs & Aging
Publisher
Springer-Verlag
Publication Date
Jun 01, 2013
Volume
30
Issue
6
Pages
409–415
Identifiers
DOI: 10.1007/s40266-013-0068-x
PMID: 23475598
Source
Medline
License
Unknown

Abstract

Lithium levels do not correlate strongly (ρ > 0.5) with decreased eGFR at 2- and 4-year follow-up in geriatric outpatients. These results are not reliably generalizable when treating patients at mean lithium levels greater than 0.8 mEq/L, especially at 4-year follow-up, and larger studies will be necessary to examine the possibility of a smaller correlation. Nonetheless, these data and the existing literature suggest that lithium levels up to 0.8 mmol/L are safe for use in the long-term treatment of geriatric patients with mood disorders without pre-existing chronic renal failure.

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