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Effect of serum concentration on the cytotoxicity and sister chromatid exchange induction by a chemical carcinogen and by a diesel particulate extract in V79 hamster cells.

Authors
  • Coulomb, H M
  • Gu, Z W
  • Loireau, M P
  • Chouroulinkov, I
Type
Published Article
Journal
Cancer Letters
Publisher
Elsevier
Publication Date
Feb 01, 1984
Volume
22
Issue
1
Pages
77–82
Identifiers
PMID: 6697323
Source
Medline
License
Unknown

Abstract

The role of serum concentration on the cytotoxicity and on the sister chromatid exchange (SCE)-induction by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and by a diesel particulate extract (DPE), a complex mixture, has been carried out on V79 cells. An increase of the serum concentration in the medium decreases the toxicity of these chemicals, and especially when they are dispersed first in serum. Although no influence of serum concentration on the number of spontaneous SCEs occurring in control cells has been observed, the increase of serum concentration leads to a decrease in SCE's induction in treated cells. Our results show that serum can protect cells from the cytotoxic and mutagenic action of MNNG and diesel extract.

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