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Effect of serotonin on the dissociation of high-affinity binding of [3H]imipramine in mouse cerebral cortex.

Authors
  • Kim, S S
  • Reith, M E
Type
Published Article
Journal
Neuroscience Letters
Publisher
Elsevier
Publication Date
Jun 18, 1986
Volume
67
Issue
2
Pages
123–128
Identifiers
PMID: 2941701
Source
Medline
License
Unknown

Abstract

A low concentration of norzimelidine can be used to selectively measure the rate of dissociation of [3H]imipramine from high-affinity binding sites in the mouse cerebral cortex. Serotonin attenuates the dissociation initiated by norzimelidine. There is no difference between the half-time of dissociation in the presence of both serotonin and norzimelidine and that in the presence of serotonin alone. These effects are similar to but much less pronounced than those observed in the platelet.

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