Affordable Access

Effect of sanguinarine on the transport of essential nutrients in an everted gut sac model: role of Na+,K(+)-ATPase.

Authors
  • Tandon, S
  • Das, M
  • Khanna, S K
Type
Published Article
Journal
Natural toxins
Publication Date
Jan 01, 1993
Volume
1
Issue
4
Pages
235–240
Identifiers
PMID: 8167940
Source
Medline
License
Unknown

Abstract

The effect of the argemone alkaloid, sanguinarine, was studied on the active transport of D-glucose and some of the L-amino acids in everted sacs of the small intestine of rats. Sanguinarine (1.0 mumole) was found to inhibit (61%) the transport of D-glucose, while an alkaloid concentration of 0.1 mumole was ineffective. Both 0.1 and 1.0 mumole of sanguinarine had no effect on the transport of the L-amino acids including aspartic acid, lysine, and tyrosine. Sanguinarine showed a dose dependent inhibition of intestinal and hepatic Na+,K(+)-ATPase in a non-competitive manner. The inhibition of Na+,K(+)-ATPase by sanguinarine may in turn inhibit the active transport of D-glucose which requires a sodium pump.

Report this publication

Statistics

Seen <100 times