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Effect of rhg-csf (filgrastim) on leukocyte kinetics and immune function in cytotoxic chemotherapy for gynecologic malignancies.

Authors
  • Takeshima, N
  • Umezawa, S
  • Shimizu, Y
  • Fukuda, M
  • Kimura, M
  • Hasumi, K
Type
Published Article
Journal
International journal of oncology
Publication Date
Oct 01, 1994
Volume
5
Issue
4
Pages
827–831
Identifiers
PMID: 21559648
Source
Medline
License
Unknown

Abstract

The effects of human recombinant granulocyte colony-stimulating factor (rhG-CSF) on leukocyte kinetics and immune function were assessed in patients with gynecologic malignancies receiving cytotoxic chemotherapy. Five day-rhG-CSF administration (50 mu g/m(2)/day) increased leukocyte counts in most of the chemotherapy courses. There was a significant difference in the leukocyte increase between the previously irradiated group and the nonirradiated group. An appreciable increase in LAK activity owing to an increased IL-2 production was noted after rhG-CSF administration. Despite a remarkable increase in the neutrophils observed, the CD57(+) cell count and NK activity in peripheral blood mononuclear cells were unexpectedly reduced.

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