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The effect of repeated amphetamine treatment on striatal DA transporter and rotation in rats.

Authors
  • Mintz, M
  • Gordon, I
  • Roz, N
  • Rehavi, M
Type
Published Article
Journal
Brain Research
Publisher
Elsevier
Publication Date
Dec 30, 1994
Volume
668
Issue
1-2
Pages
239–242
Identifiers
PMID: 7704609
Source
Medline
License
Unknown

Abstract

The effect of repeated amphetamine treatment on the involvement of the striatal DA transporters in rotation behavior was tested in rats. Repeated amphetamine treatment had no effect on [3H]DA uptake or [3H]GBR-12935 binding density. However, unlike the naive rats who rotated away from the striatum with a lower density of DA transporters, rats sensitized to amphetamine rotated toward the striatum with a lower density of DA transporters. These findings imply that repeated amphetamine augments the subcortical involvement in behavioral output.

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