The effect of repeated amphetamine treatment on striatal DA transporter and rotation in rats.
- Published Article
- Publication Date
Dec 30, 1994
The effect of repeated amphetamine treatment on the involvement of the striatal DA transporters in rotation behavior was tested in rats. Repeated amphetamine treatment had no effect on [3H]DA uptake or [3H]GBR-12935 binding density. However, unlike the naive rats who rotated away from the striatum with a lower density of DA transporters, rats sensitized to amphetamine rotated toward the striatum with a lower density of DA transporters. These findings imply that repeated amphetamine augments the subcortical involvement in behavioral output.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/7704609