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[The effect of pyrazidole on monoamine level in hypobaric hypoxia].

Authors
Type
Published Article
Journal
Voprosy medit︠s︡inskoĭ khimii
Publication Date
Volume
40
Issue
1
Pages
16–18
Identifiers
PMID: 8122400
Source
Medline

Abstract

Increase of serotonin content and decrease in 5-hydroxyindolyl acetic acid (5-HIAA) were observed under hypoxic conditions (9,000 m, 3 hrs) which correlated with inhibition of monoamine oxidase A. Administration of the monoamine oxidase inhibitor pyrazidole caused the more pronounced increase of serotonin levels and decrease of 5-HIAA in control animals as well as in hypoxic animals. The catecholamines increased in hypoxia, pretreatment with pyrazidole prevented this increase. Preliminary administration of pyrazidole also increased the content of blood catecholamines, which reduced in hypoxia. Pyrazidole exhibited the antistress effect as the drug inhibited a decrease in adrenal ascorbic acid levels in hypoxic conditions.

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