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Effect of prostaglandin I2 on platelet adhesion.

Authors
  • Fésüs, L
  • Hársfalvi, J
  • Kovács, E
  • Muszbek, L
  • Stadler, I
Type
Published Article
Journal
Biomaterials
Publisher
Elsevier
Publication Date
Jan 01, 1981
Volume
2
Issue
1
Pages
53–54
Identifiers
PMID: 7016206
Source
Medline
License
Unknown

Abstract

The adherence of platelets to collagen fibrils was not affected by prostaglandin I2 (PGI2) applied in a wide concentration range (0.1-100 ng/ml). The retention of platelets on glass beads which includes adhesion as well as subsequent clumping of platelets was, however, greatly reduced at PGI2 concentrations higher than 0.5 ng/ml. The results suggest that PGI2 even at high concentration does not interfere with the primary process of platelet adhesion, i.e., with the formation of a monocellular platelet layer on collagen fibrils and artificial surfaces, but it inhibits clumping of further platelets to this layer and prevents subsequent platelet thrombus formation.

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