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Effect of prostaglandin E receptor subtype EP4 selective agonist on the secretion of tumor necrosis factor-alpha by macrophages in acute ethanol-loaded rats.

Authors
  • Nakatani, Yoshihiro
  • Kitazawa, Toshiyuki
  • Fujimoto, Masao
  • Tamura, Nobuhiro
  • Uemura, Masahito
  • Yamao, Junichi
  • Fukui, Hiroshi
Type
Published Article
Journal
Alcoholism, clinical and experimental research
Publication Date
Aug 01, 2004
Volume
28
Issue
8 Suppl Proceedings
Identifiers
PMID: 15318098
Source
Medline
License
Unknown

Abstract

An EP4 agonist ONO-AE1-437 suppresses excess TNF-alpha secretion from macrophages and seems promising for future trial in patients with severe alcoholic hepatitis.

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