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Effect of pomegranate seed oil supplementation on the GLUT-4 gene expression and glycemic control in obese people with type 2 diabetes: A randomized controlled clinical trial.

Authors
  • Khajebishak, Yaser1
  • Payahoo, Laleh2
  • Alivand, Mohammadreza3
  • Hamishehkar, Hamed4
  • Mobasseri, Majid5
  • Ebrahimzadeh, Vahide2
  • Alipour, Mahdiye6
  • Alipour, Beitollah7
  • 1 Talented Student Center, Student Research Committee, Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. , (Iran)
  • 2 Department of Nutrition, Maragheh University of Medical Sciences, Maragheh, Iran. , (Iran)
  • 3 Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. , (Iran)
  • 4 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. , (Iran)
  • 5 Endocrinology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. , (Iran)
  • 6 Dental and Periodontal Research Center, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran. , (Iran)
  • 7 Department of Community Nutrition, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran. , (Iran)
Type
Published Article
Journal
Journal of Cellular Physiology
Publisher
Wiley (John Wiley & Sons)
Publication Date
Nov 01, 2019
Volume
234
Issue
11
Pages
19621–19628
Identifiers
DOI: 10.1002/jcp.28561
PMID: 30945297
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Abnormality in glucose transporter type 4 (GLUT-4) function and insulin secretion are the main causes of type 2 diabetes mellitus (T2DM). Due to adverse effects of antidiabetic drugs, nowadays, nutraceuticals have been of much interest to investigators. The aim of the present study was to determine the effect of pomegranate seed oil (PSO) on the GLUT-4 gene expression and glycemic control in obese people with T2DM. This randomized clinical trial was conducted on 52 obese type 2 diabetic patients for 8 weeks in Tabriz, Iran, in 2018. Patients were divided into the intervention group (n = 26; who consumed daily three capsules containing 1 g PSO) and the placebo group (n = 26; the same amounts paraffin). GLUT-4 gene expression and glycemic indices were evaluated by standard methods. GLUT-4 gene expression was increased significantly in the PSO group. Within-group changes in fasting blood sugar (FBS) and quantitative insulin sensitivity check index were significant in the PSO group. After adjusting the age, gender, and baseline values, FBS was significantly decreased. Insulin concentration, HbA1C, HOMA-IR, and HOMA-β did not manifest significant changes. PSO increased the GLUT-4 gene expression in diabetic patients without any side effects. However, future clinical studies are needed to confirm the obtained results. © 2019 Wiley Periodicals, Inc.

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