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The effect of platelet-activating factor (PAF) on nasal airway resistance in healthy subjects is not mediated by nitric oxide.

Authors
  • Maniscalco, M
  • Sofia, M
  • Faraone, S
  • Carratù, L
Type
Published Article
Journal
Allergy
Publication Date
Aug 01, 2000
Volume
55
Issue
8
Pages
757–761
Identifiers
PMID: 10955702
Source
Medline
License
Unknown

Abstract

Topical administration of the NO-synthase inhibitor L-NAME at doses sufficient to decrease NO nasal production does not prevent the PAF-induced increase in NAR, indicating that NO generation in vivo is not involved in the nasal response to PAF.

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