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The effect of Plasmodium falciparum exo-antigens on the morphology of uninfected erythrocytes.

Authors
  • Read, D G
  • Bushell, G R
  • Kidson, C
Type
Published Article
Journal
Parasitology
Publication Date
Apr 01, 1990
Volume
100 Pt 2
Pages
185–190
Identifiers
PMID: 2189113
Source
Medline
License
Unknown

Abstract

It was observed that uninfected red cells resuspended in supernatant from Plasmodium falciparum cultures, then examined between a glass slide and cover-slip, assumed varying morphologies. A series of experiments suggested that P. falciparum releases molecules which cause red cells to become stomatocytic (cupped). These molecules, some of which are heat-stable have an apparent molecular weight greater than 12 kDa, are released at or about schizogony, and do not bind tightly to erythrocytes.

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