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The effect of plasma auto-IgGs on CD4+ T cell apoptosis and recovery in HIV-infected patients under antiretroviral therapy.

Authors
  • Luo, Zhenwu1
  • Zhou, Zejun1
  • Ogunrinde, Elizabeth1
  • Zhang, Tao1, 2
  • Li, Zhen3
  • Martin, Lisa4
  • Wan, Zhuang1
  • Wu, Hao3
  • Qin, Zhiqiang5
  • Ou, Tongwen6
  • Zhang, Jiafeng7
  • Ma, Lei8
  • Liao, Guoyang8
  • Heath, Sonya9
  • Huang, Lei10
  • Jiang, Wei11, 2
  • 1 Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina, USA.
  • 2 The First Affiliated Hospital of Hu-Nan University of Chinese Medicine, Changsha, China. , (China)
  • 3 Beijing You'an Hospital, Capital Medical University, Fengtai District, Beijing, China. , (China)
  • 4 Division of Infectious Diseases, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
  • 5 Department of Genetics, Louisiana Cancer Research Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.
  • 6 Capital Medical University Affiliated XuanWu Hospital, Xicheng District, Beijing, China. , (China)
  • 7 Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China. , (China)
  • 8 Biologicals Department, Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kuming, China. , (China)
  • 9 Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA; and.
  • 10 The People's Liberation Army No. 302 Hospital, Treatment and Research Center for Infectious Diseases, Beijing, China [email protected] , (China)
  • 11 Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina, USA; [email protected]
Type
Published Article
Journal
Journal of Leukocyte Biology
Publisher
Wiley (John Wiley & Sons)
Publication Date
Dec 01, 2017
Volume
102
Issue
6
Pages
1481–1486
Identifiers
DOI: 10.1189/jlb.5A0617-219R
PMID: 29030391
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Although effective antiretroviral therapy (ART) suppresses HIV viral replication, prevents AIDS-related complications, and prolongs life, a proportion of patients fails to restore the patients' CD4+ T cell number to the level of healthy individuals. Increased mortality and morbidity have been observed in these patients. In the current study, we have investigated the role of auto-IgGs in CD4+ T cell apoptosis and recovery in a cross-sectional study. All HIV+ subjects were on viral-suppressive ART treatment with a different degree of CD4+ T cell reconstitution. Total auto-IgG binding on CD4+ T cell surfaces and its associated apoptosis and CD4+ T cell recovery were analyzed by flow cytometry ex vivo. Total IgGs from plasma were tested for their binding capacities to CD4+ T cell surfaces and their mediation to CD4+ T cell death through NK cell cytotoxicity in vitro. HIV+ subjects had increased surface binding of auto-IgGs on CD4+ T cells compared with healthy controls, and IgG binding was associated with elevated CD4+ T cell apoptosis in HIV+ subjects but not in healthy controls. Plasma IgGs from HIV+ subjects bound to CD4+ T cells and induced cell apoptosis through NK cytotoxicity in vitro. Soluble CD4 (sCD4) preincubation prevented NK cell-mediated CD4+ T cell death. Our results suggest that plasma autoantibodies may play a role in some HIV+ patients with poor CD4+ T cell recovery under viral-suppressive ART. © Society for Leukocyte Biology.

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