Burn injuries cause significant physical impairments that need comprehensive rehabilitation and coordination with the acute burn care team. Music had been shown to increase positive mood during exercise, which may result in motivation for participation in exercise programs. The current study aimed to evaluate the effect of physical therapy rehabilitation program combined with music therapy on children with lower limb burns. A twelve-week randomized controlled study including thirty pediatrics with lower limb burns. They were randomly assigned into two equal groups, 15 children per each. Group A received a physical therapy rehabilitation program combined with music therapy in addition to routine medical care. However, Group B received a physical therapy rehabilitation program without music therapy. Assessment of pain was by visual analogue scale (VAS), assessment of the range of motion (ROM) by goniometer, and gait assessed by GAIT Rite. The evaluation was carried before and after the interventions. Before starting the study, no significant differences were detected between the two study groups (p < 0.05). The study results reported statistically significant improvement in VAS, ROM, and GAIT Rite in both groups after the intervention (p < 0.05). Group A showed greater improvement than group B in all outcome measures (p < 0.05). Physical therapy program combined with music therapy is an effective and safe modality for improving pain, range of motion, and gait parameters in pediatrics with lower limb burn. Also, physical therapy combined with music therapy is more effective than physical therapy alone in the treatment of pediatrics with lower limb burns. Copyright © 2020 Elsevier Ltd and ISBI. All rights reserved.